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Page 1
Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans.
Axelrod CL, Fealy CE, Erickson ML, Davuluri G, Fujioka H, Dantas WS, Huang E, Pergola K, Mey JT, King WT, Mulya A, Hsia D, Burguera B, Tandler B, Hoppel CL, Kirwan JP. Axelrod CL, et al. Among authors: king wt. Metabolism. 2021 Aug;121:154803. doi: 10.1016/j.metabol.2021.154803. Epub 2021 Jun 4. Metabolism. 2021. PMID: 34090870 Free PMC article. Clinical Trial.
BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control.
Axelrod CL, King WT, Davuluri G, Noland RC, Hall J, Hull M, Dantas WS, Zunica ER, Alexopoulos SJ, Hoehn KL, Langohr I, Stadler K, Doyle H, Schmidt E, Nieuwoudt S, Fitzgerald K, Pergola K, Fujioka H, Mey JT, Fealy C, Mulya A, Beyl R, Hoppel CL, Kirwan JP. Axelrod CL, et al. Among authors: king wt. EMBO Mol Med. 2020 Jul 7;12(7):e12088. doi: 10.15252/emmm.202012088. Epub 2020 Jun 10. EMBO Mol Med. 2020. PMID: 32519812 Free PMC article.
Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics.
King WT, Axelrod CL, Zunica ERM, Noland RC, Davuluri G, Fujioka H, Tandler B, Pergola K, Hermann GE, Rogers RC, López-Domènech S, Dantas WS, Stadler K, Hoppel CL, Kirwan JP. King WT, et al. J Biol Chem. 2021 Oct;297(4):101196. doi: 10.1016/j.jbc.2021.101196. Epub 2021 Sep 13. J Biol Chem. 2021. PMID: 34529976 Free PMC article.
Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15.
Zunica ERM, Axelrod CL, Cho E, Spielmann G, Davuluri G, Alexopoulos SJ, Beretta M, Hoehn KL, Dantas WS, Stadler K, King WT, Pergola K, Irving BA, Langohr IM, Yang S, Hoppel CL, Gilmore LA, Kirwan JP. Zunica ERM, et al. Among authors: king wt. Cancer Metab. 2021 Oct 9;9(1):36. doi: 10.1186/s40170-021-00274-5. Cancer Metab. 2021. PMID: 34627389 Free PMC article.
β-Hydroxybutyrate is reduced in humans with obesity-related NAFLD and displays a dose-dependent effect on skeletal muscle mitochondrial respiration in vitro.
Mey JT, Erickson ML, Axelrod CL, King WT, Flask CA, McCullough AJ, Kirwan JP. Mey JT, et al. Among authors: king wt. Am J Physiol Endocrinol Metab. 2020 Jul 1;319(1):E187-E195. doi: 10.1152/ajpendo.00058.2020. Epub 2020 May 12. Am J Physiol Endocrinol Metab. 2020. PMID: 32396388 Free PMC article.
12 results